Rho-Conotoxin-TIA
Blocker of α1-adrenoreceptor
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產品名稱: Rho-Conotoxin-TIA
Blocker of α1-adrenoreceptor
產品型號: CON022-00100
產品展商: 其他品牌
產品文檔: 無相關文檔
簡單介紹
Rho-Conotoxin-TIA
Blocker of α1-adrenoreceptor
Rho-conotoxin TIA is a conopeptide that has been isolated from the venom of the fish-hunting marine cone snail Conus tulipa. Rho-conotoxin TIA is a selective antagonist of α1-adrenoreceptor (α1A-, α1B– and α1D-AR). It acts non-competitively onto α1B-adrenoreceptor but competitively on α1A-adrenoreceptor and α1D-adrenoreceptor. The most important resi
Rho-Conotoxin-TIA
Blocker of α1-adrenoreceptor
的詳細介紹
Rho-Conotoxin-TIA
Blocker of α1-adrenoreceptor
Rho-conotoxin TIA is a conopeptide that has been isolated from the venom of the fish-hunting marine cone snail Conus tulipa. Rho-conotoxin TIA is a selective antagonist of α1-adrenoreceptor (α1A-, α1B– and α1D-AR). It acts non-competitively onto α1B-adrenoreceptor but competitively on α1A-adrenoreceptor and α1D-adrenoreceptor. The most important residue for activity is Arg4. Rho-conotoxin TIA is 10-fold selective for human α1B-adrenoreceptor over α1A-adrenoreceptor and α1D-adrenoreceptor. The IC50 values for Rho-conotoxin TIA for inhibition of 125I-BE were 18 nM for human α1A-AR, 2 nM for α1B-AR and 25 nM for α1D-AR.
