GsMTx4
Selective blocker of mechanosensitive ion channels
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產(chǎn)品名稱: GsMTx4
Selective blocker of mechanosensitive ion channels
產(chǎn)品型號(hào): 08GSM001-00050
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡(jiǎn)單介紹
GsMTx4
Selective blocker of mechanosensitive ion channels
GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin ac
GsMTx4
Selective blocker of mechanosensitive ion channels
的詳細(xì)介紹
GsMTx4
Selective blocker of mechanosensitive ion channels
GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1μM concentration and to inhibit Piezo1 currents.
