Recombinant Human Kit ligand protein(KITLG) (Active)
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產(chǎn)品名稱: Recombinant Human Kit ligand protein(KITLG) (Active)
產(chǎn)品型號:
產(chǎn)品展商: 其它品牌
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簡單介紹
Recombinant Human Kit ligand protein(KITLG) (Active)
Recombinant Human Kit ligand protein(KITLG) (Active)
的詳細介紹
產(chǎn)品類型:Colony Stimulating Factor
產(chǎn)品名稱:Recombinant Human Kit ligand protein(KITLG) (Active)
uniprot號:
規(guī)格:
￥620
圖像:
基因名稱:
KITLG
別名:
Mast cell growth factor, Stem cell factor, SCF, c-Kit ligand
種屬:
Homo sapiens (Human)
蛋白描述:
Partial
PubMed ID:
1724381
分子量:
18.5 kDa
標簽信息:
Tag-Free
來源:
E.Coli
純度:
>97% as determined by SDS-PAGE and HPLC.
緩沖液:
0.2 μm filtered PBS, pH 7.4 ,lyophilized
內(nèi)毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 2 ng/ml, corresponding to a specific activity of >5.0x10
5 IU/mg.
SCF_HUMAN
參考文獻:
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
氨基酸序列:
EGICRNRVTN NVKDVTKLVA NLPKDYMITL KYVPGMDVLP SHCWISEMVV QLSDSLTDLL DKFSNISEGL SNYSIIDKLV NIVDDLVECV KENSSKDLKK SFKSPEPRLF TPEEFFRIFN RSIDAFKDFV VASETSDCVV SSTLSPEKDS RVSVTKPFML PPVA
表達區(qū)域:
26-189aa
研究領域:
Immunology
