Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)
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產品名稱: Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)
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簡單介紹
Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)
Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)
的詳細介紹
產品類型:Chemokine
產品名稱:Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)
uniprot號:
規格:
￥620
圖像:
基因名稱:
CCL4
別名:
G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69
種屬:
Homo sapiens (Human)
蛋白描述:
Partial of NM_207007.3
PubMed ID:
2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 15843566; 16625196; 15489334; 2809212; 9521068; 8525373; 10540332; 12070155; 12401480; 8134838
分子量:
7.8 kDa
標簽信息:
Tag-Free
來源:
E.Coli
純度:
>97% as determined by SDS-PAGE and HPLC.
緩沖液:
0.2 μm filtered PBS, pH 7.4 ,lyophilized
內毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of >5.0x10
5 IU/mg.
CCL4_HUMAN
參考文獻:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
氨基酸序列:
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
表達區域:
24-92aa
研究領域:
Immunology
