Recombinant Human Interleukin-33 protein(IL33) (Active)
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產品名稱: Recombinant Human Interleukin-33 protein(IL33) (Active)
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簡單介紹
Recombinant Human Interleukin-33 protein(IL33) (Active)
Recombinant Human Interleukin-33 protein(IL33) (Active)
的詳細介紹
產品類型:Interleukin
產品名稱:Recombinant Human Interleukin-33 protein(IL33) (Active)
uniprot號:
規格:
￥620
圖像:
基因名稱:
IL33
別名:
IL-33, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV
種屬:
Homo sapiens (Human)
蛋白描述:
Partial
PubMed ID:
12819012; 10566975; 16286016; 21454686; 14702039; 15164053; 15489334; 22307629; 17853410; 17185418; 18787100; 18836528; 19596270; 19559631; 19465481; 19439663; 21734074; 22215666; 19836339; 23980170
分子量:
17.9 kDa
標簽信息:
Tag-Free
來源:
E.Coli
純度:
>97% as determined by SDS-PAGE and HPLC.
緩沖液:
0.2μm filtered 20 mM PB, 150 mM NaCl, 1mM EDTA, pH7.4 ,lyophilized
內毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x10
7 IU/mg.
IL33_HUMAN
參考文獻:
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). {ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:21734074}.
氨基酸序列:
SITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVLLSYYESQHPS NE SGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEKPLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
表達區域:
112-270aa
研究領域:
Immunology
