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Anti-FAS Antibody

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產(chǎn)品名稱: Anti-FAS Antibody
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簡單介紹

Anti-FAS Antibody


Anti-FAS Antibody  的詳細介紹
Name: Anti-FAS Antibody
See all FAS primary antibodies
Description: Rabbit polyclonal antibody to FAS
Specificity: The antibody detects endogenous levels of total Fas protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthesized peptide derived from C-terminal of human Fas.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Tissue Specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Involvement in Disease: Autoimmune lymphoproliferative syndrome 1A: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Post-Translational Modification: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 355?Human
  • Omim: 134637?Human
  • SwissProt: P25445?Human
  • Unigene: 244139?Human
    		•
    Synonyms:
  • ALPS 1A Antibody
  • ALPS1A Antibody
  • APO 1 Antibody
  • Apo 1 antigen Antibody
  • APO 1 cell surface antigen Antibody
  • Apo-1 antigen Antibody
  • APO1 Antibody
  • Apo1 antigen Antibody
  • APO1 cell surface antigen Antibody
  • Apoptosis antigen 1 Antibody
  • Apoptosis mediating surface antigen FAS Antibody
  • Apoptosis-mediating surface antigen FAS Antibody
  • APT 1 Antibody
  • APT1 Antibody
  • CD 95 Antibody
  • CD 95 antigen Antibody
  • CD95 Antibody
  • CD95 antigen Antibody
  • Delta Fas Antibody
  • Delta Fas/APO 1/CD95 Antibody
  • Delta Fas/APO1/CD95 Antibody
  • Fas Antibody
  • Fas (TNF receptor superfamily, member 6) Antibody
  • FAS 1 Antibody
  • FAS 827dupA Antibody
  • Fas AMA Antibody
  • FAS Antigen Antibody
  • Fas cell surface death receptor Antibody
  • FAS1 Antibody
  • FASLG receptor Antibody
  • FASTM Antibody
  • sFAS Antibody
  • Surface antigen APO1 Antibody
  • TNF receptor superfamily, member 6 Antibody
  • TNFRSF 6 Antibody
  • TNFRSF6 Antibody
  • TNR6_HUMAN Antibody
  • Tumor necrosis factor receptor superfamily member 6 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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