Anti-FANCM Antibody
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產品名稱: Anti-FANCM Antibody
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簡單介紹
Anti-FANCM Antibody
的詳細介紹
Overview
| Name: |
Anti-FANCM Antibody See all FANCM primary antibodies
|
| Description: |
Rabbit polyclonal antibody to FANCM. |
| Applications: |
WB, IF |
| Dilutions: |
WB: 1:500 - 1:2000, IF: 1:50 - 1:100. |
| Reactivity: |
Human |
| Immunogen: |
Recombinant protein of human FANCM. |
| Protein Length: |
2048 |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Conjugate: |
Unconjugated |
| Purification: |
Affinity purification. |
| Product Form: |
Liquid |
| Formulation: |
Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: |
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). |
| Sequence Similarities: |
Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. |
| Post-Translational Modification: |
Phosphorylated; hyperphosphorylated in response to genotoxic stress. |
| Cellular Location: |
Nucleus. |
| Database Links: |
Entrez Gene: 57697?HumanOmim: 609644?HumanSwissProt: Q8IYD8?HumanUnigene: 509229?Human |
| Synonyms: |
ATP-dependent RNA helicase FANCM AntibodyFAAP250 AntibodyFANCM AntibodyFanconi anemia group M protein Antibodyfanconi anemia-associated polypeptide of 250 kDa AntibodyKIAA1596 AntibodyProtein Hef ortholog Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
