Anti-FANCC Antibody
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產品名稱: Anti-FANCC Antibody
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簡單介紹
Anti-FANCC Antibody
的詳細介紹
Overview
| Name: |
Anti-FANCC Antibody See all FANCC primary antibodies
|
| Description: |
Rabbit polyclonal antibody to FANCC |
| Specificity: |
The antibody detects endogenous level of total FANCC protein. |
| Applications: |
WB, IHC, IF |
| Reactivity: |
Human |
| Immunogen: |
Recombinant protein of human FANCC. |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Purification: |
Antibodies were purified by affinity purification using immunogen. |
| Concentration: |
1.0mg / ml |
| Formulation: |
Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage: |
Store at -20?C |
Target
| Function: |
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. |
| Tissue Specificity: |
Ubiquitous. |
| Involvement in Disease: |
Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| Cellular Location: |
Nucleus. Cytoplasm.
The major form is nuclear. The minor form is cytoplasmic. |
| Database Links: |
Entrez Gene: 2176?HumanOmim: 613899?HumanSwissProt: Q00597?HumanUnigene: 494529?Human |
| Synonyms: |
bA80I15.1 AntibodyFA 3 AntibodyFA3 AntibodyFAC AntibodyFACC AntibodyFANCC AntibodyFANCC_HUMAN AntibodyFanconi anemia complementation group C AntibodyFanconi anemia complementation group C protein AntibodyFanconi anemia group C protein AntibodyFanconi pancytopenia type 3 AntibodyFLJ14675 AntibodyProtein FACC Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
