Anti-FANCC Antibody
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產品名稱: Anti-FANCC Antibody
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簡單介紹
Anti-FANCC Antibody
的詳細介紹
Overview
| Name: |
Anti-FANCC Antibody See all FANCC primary antibodies
|
| Description: |
Rabbit polyclonal antibody to FANCC. |
| Applications: |
WB, IHC, IF |
| Dilutions: |
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200. |
| Reactivity: |
Human |
| Immunogen: |
Recombinant protein of human FANCC. |
| Protein Length: |
558 |
| Host: |
Rabbit |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Conjugate: |
Unconjugated |
| Purification: |
Affinity purification. |
| Product Form: |
Liquid |
| Formulation: |
Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: |
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. |
| Tissue Specificity: |
Ubiquitous. |
| Involvement in Disease: |
Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| Cellular Location: |
Nucleus. Cytoplasm.
The major form is nuclear. The minor form is cytoplasmic. |
| Database Links: |
Entrez Gene: 2176?HumanOmim: 613899?HumanSwissProt: Q00597?HumanUnigene: 494529?Human |
| Synonyms: |
bA80I15.1 AntibodyFA 3 AntibodyFA3 AntibodyFAC AntibodyFACC AntibodyFANCC AntibodyFANCC_HUMAN AntibodyFanconi anemia complementation group C AntibodyFanconi anemia complementation group C protein AntibodyFanconi anemia group C protein AntibodyFanconi pancytopenia type 3 AntibodyFLJ14675 AntibodyProtein FACC Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
