UF010,HDACInhibitor
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產品名稱: UF010,HDACInhibitor
產品型號: M60278-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
UF010,HDACInhibitor
UF010,HDACInhibitor
的詳細介紹
Product Information
| Molecular Weight: |
271.15 |
| Formula: |
C11H15BrN2O |
| Purity: |
≥98% |
| CAS#: |
537672-41-6 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
4-bromo-N'-butylbenzohydrazide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
UF010 is a potent and selective class I HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has >6-fold selectivity over other HDACs, and is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines.
How to Use:
In vitro: UF010 was used at 5-10 μM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
- 1. Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. (2015) Chem Biol. 22(2):273-84.
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Products are for research use only. Not for human use.?
