OF-1,BRPFBromodomainInhibitor
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產(chǎn)品名稱: OF-1,BRPFBromodomainInhibitor
產(chǎn)品型號: M60222-2s
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
OF-1,BRPFBromodomainInhibitor
OF-1,BRPFBromodomainInhibitor
的詳細(xì)介紹
Product Information
| Molecular Weight: |
440.31 |
| Formula: |
C17H18BrN3O4S
|
| Purity: |
≥98% |
| CAS#: |
919973-83-4 |
| Solubility: |
DMSO up to 20 mM |
| Chemical Name: |
4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
OF-1 is
the potent and selective BRPF (BRomodomain and PHD Finger
containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2
with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 mM (ITC). It has
general >100-fold selectivity against other bromodomains (39-fold
selectivity over BRD4). OF-1 increases thermal stability in the cellular
thermal shift assay (CETSA) of full length BRPF1B at 1 μM and also demonstrates
accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. It shows modest
general cytotoxicity.
How to Use:
- In vitro:?
OF-1 was used at 5-10 μM final concentration in various in vitro assays.
- In vivo: n/a?
Reference
- ?http://www.thesgc.org/chemical-probes/OF-1?
ProProducts are for research use only. Not for human use.?
