NSC636819,KDM4A/KDM4BInhibitor
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產品名稱: NSC636819,KDM4A/KDM4BInhibitor
產品型號: M60290-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
NSC636819,KDM4A/KDM4BInhibitor
NSC636819,KDM4A/KDM4BInhibitor
的詳細介紹
Product Information
| Molecular Weight: |
510.15 |
| Formula: |
C22H12Cl4N2O4 |
| Purity: |
≥98% |
| CAS#: |
1618672-71-1 |
| Solubility: |
DMSO up to 10 mM |
| Chemical Name: |
4,4'-((1E,1'E)-(4,6-dinitro-1,3-phenylene)bis(ethene-2,1-diyl))bis(1,2-dichlorobenzene) |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
NSC636819 is a cell permeable and selective novel active-site KDM4A/KDM4B inhibitor with IC50 ~6.4 μM for KDM4A and 9.3 μM for KDM4B. It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. It also negatively regulates androgen-responsive genes. The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer.
How to Use:
In vitro: NSC636819 was used at 10 μM final concentration in vitro and in cellular assays.
In vivo: n/a
Reference:
- 1. Chu CH, et al. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. (2014) J Med Chem. 57(14):5975-85.?
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Products are for research use only. Not for human use.?
