MRT68921,AutophagyKinaseULK1/2Inhibitor
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: MRT68921,AutophagyKinaseULK1/2Inhibitor
產(chǎn)品型號: M60311-2s
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無相關文檔
簡單介紹
MRT68921,AutophagyKinaseULK1/2Inhibitor
MRT68921,AutophagyKinaseULK1/2Inhibitor
的詳細介紹
Product Information
| Molecular Weight: |
464.61 |
| Formula: |
C26H36N6O2 |
| Purity: |
≥98% |
| CAS#: |
1190378-57-4 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
N-(3-((5-cyclopropyl-2-((3-(morpholinomethyl)phenyl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
MRT68921 is a potent, selective and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. It can inhibit ULK in vitro and block autophagy in cells. By generating the drug-resistant M92T ULK1 mutant, MRT68921demostrates to specifically block autophagic flux through ULK1 inhibition and disrupt autophagosome maturation, not through AMPK-related kinase involvement. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.
How to Use:
In vitro: MRT68921 was usually used at 1 μM final concentration in vitro.
In vivo: n/a
Reference:
- 1. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. (2015) J Biol Chem. 290(18):11376-83.?
? ? ??? ? ??
Products are for research use only. Not for human use.?
