IWP-2,Porcupine(Wnt)Inhibitor
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產品名稱: IWP-2,Porcupine(Wnt)Inhibitor
產品型號: M60115-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
IWP-2,Porcupine(Wnt)Inhibitor
IWP-2,Porcupine(Wnt)Inhibitor
的詳細介紹
Product Information
| Molecular Weight: |
466.60 |
| Formula: |
C22H18N4O2S3 |
| Purity: |
≥98% |
| CAS#: |
686770-61-6 |
| Solubility: |
DMSO up to 10 mM |
| Chemical Name: |
N-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
IWP-2 is a potent and highly selective Wnt signaling antagonist with an IC50?~ 27 nM in the L-Wnt-STF cellular assay. It prevents palmitoylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase), thereby blocking Wnt protein secretion and activity. It blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP-2 is a useful chemical probe in both regenerative medicine and anticancer efforts.
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How to Use:
- In vitro:?IWP-2 was used at 1-2 μM in vitro and in cellular assays.
- In vivo:?n/a
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Reference:?
- 1. Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. (2009) Nat Chem Biol. 5(2):100-7.
- 2. ten Berge D, et al. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. (2011) Nat Cell Biol. 13(9):1070-5.
- 3. Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. (2012) Proc Natl Acad Sci USA. 109(27):E1848-57. ? ? ?
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Products are for research use only. Not for human use.
