IOX2,HIFProlyl-Hydroxylases(PHD2)Inhibitor
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產(chǎn)品名稱: IOX2,HIFProlyl-Hydroxylases(PHD2)Inhibitor
產(chǎn)品型號(hào): M66054-2s
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
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IOX2,HIFProlyl-Hydroxylases(PHD2)Inhibitor
IOX2,HIFProlyl-Hydroxylases(PHD2)Inhibitor
的詳細(xì)介紹
Product Information
| Molecular Weight: |
352.34 |
| Formula: |
C19H16N2O5 |
| Purity: |
≥98% |
| CAS#: |
931398-72-0 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
IOX2 is a potent, selective and cell permeable inhibitor of hypoxia inducible factor 1α (HIF1α) prolyl hydroxylase-2 (PHD2). It inhibits PHD2 with an IC50?~21 nM, and exhibits over 100-fold selectivity against JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM.
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How to Use:
- ?In vitro:??IOX2 was usually used at 10-50μM final concentration in vitro
- ?In vivo:?n/a
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Reference:
- 1. Murray JK, et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. (2010) J Comb Chem. 12(5):676-86.
- 2. SGC website:?http://www.thesgc.org/scientists/chemical_probes/IOX2
- 3. Tian YM, et al. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. (2011) J Biol Chem. 286(15):13041-51.
Products are for research use only. Not for human use.
