IOX1,2OGOxygenasesInhibitor
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產(chǎn)品名稱: IOX1,2OGOxygenasesInhibitor
產(chǎn)品型號: M60195-2s
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IOX1,2OGOxygenasesInhibitor
IOX1,2OGOxygenasesInhibitor
的詳細(xì)介紹
Product Information
| Molecular Weight: |
189.17 |
| Formula: |
C10H7NO3 |
| Purity: |
≥98% |
| CAS#: |
5852-78-8 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
8-hydroxyquinoline-5-carboxylic acid |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
IOX1 is a cell-permeable broad-spectrum inhibitor of most 2OG oxygenases. ?It inhibits histone demethylase JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX with IC50?at 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM respectively. IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
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How to Use:
- In vitro:? IOX1 was used at 10-300 μM final concentration in various in vitro assays.
- In vivo:??n/a?
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Reference:
- 1. King ON, et al. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. (2010) PLoS One. 5(11):e15535.
- 2. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. (2014) ChemMedChem. 9(3):566-71.
- 3. http://?http://www.thesgc.org/chemical-probes/IOX1
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Products are for research use only. Not for human use.
