IDH2-C100,IHD2Inhibitor
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: IDH2-C100,IHD2Inhibitor
產(chǎn)品型號(hào): M60190-2s
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
IDH2-C100,IHD2Inhibitor
IDH2-C100,IHD2Inhibitor
的詳細(xì)介紹
Product Information
| Molecular Weight: |
305.38 |
| Formula: |
C18H19N5 |
| Purity: |
≥98% |
| CAS#: |
n/a |
| Solubility: |
DMSO up to 50 mM |
| Chemical Name: |
N2-isopropyl-N4,6-diphenyl-1,3,5-triazine-2,4-diamine |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:?
IDH2-C100 is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431. It can inhibit the enzymatic activity of IDH2 R140Q and R172K in vitro with an IC50?< 0.1 μM. It has IC50?< 0.1 μM in U87MG pLVX-IDH2 R140Q-neo cell based assay. It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis.
?
How to Use:
- In vitro:?IDH2-C100 was used at 1-5 μM in vitro and cellular assays.
- In vivo:?n/a
?
Reference:
- 1. Giovanni Cianchetta, et al. Therapeutically active compounds and their methods of use. (2013) PCT WO 2013102431
?
?
?
Products are for research use only. Not for human use.
