Hh-Ag1.5,HedgehogAgonist
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產品名稱: Hh-Ag1.5,HedgehogAgonist
產品型號: M60004-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
Hh-Ag1.5,HedgehogAgonist
Hh-Ag1.5,HedgehogAgonist
的詳細介紹
Product Information
| Molecular Weight: |
526.04 |
| Formula: |
C28H26ClF2N3OS |
| Purity: |
≥98% |
| CAS#: |
612542-14-0 |
| Solubility: |
DMSO up to 50 mM |
| Chemical Name: |
3-chloro-4,7-difluoro-N-(4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:?
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50?~1 nM. Studies showed that it has more potent activity than the recombinant Hh protein in activating Smo and hedgehog pathway.
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How to Use:
- In vitro:?Hh-Ag1.5 was used at 25 nM to induce Hh pathway activation in the reporter gene assay. It was suggested to use at 0.1 μM to replace recombinant Hh protein.
- In vivo:?n/a
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Reference:
- 1.? Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. (2002) Journal of Biology (1): 10.2-10.19.
- 2.? Borzillo GV, et al. The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery. (2005) Current Topics in Medicinal Chemistry (5), 147-157.
- 3.? Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.
Products are for research use only. Not for human use. |
