GSK-LSD1,LSD1Inhibitor
如果您對該產品感興趣的話,可以
產品名稱: GSK-LSD1,LSD1Inhibitor
產品型號: M60179-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
GSK-LSD1,LSD1Inhibitor
GSK-LSD1,LSD1Inhibitor
的詳細介紹
Product Information
| Molecular Weight: |
289.24 |
| Formula: |
C14H22Cl2N2 |
| Purity: |
≥98% |
| CAS#: |
?1431368-48-7 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50?~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).? GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM).?
?
How to Use:
- In vitro:? GSK-LSD1 was used at 1 μM in vitro.
- In vivo:??n/a
?
Reference:
- 1. http://www.thesgc.org/chemical-probes/epigenetics
?
Products are for research use only. Not for human use.
