CAY10603,HDAC6Inhibitor
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產品名稱: CAY10603,HDAC6Inhibitor
產品型號: M60234-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
CAY10603,HDAC6Inhibitor
CAY10603,HDAC6Inhibitor
的詳細介紹
Product Information
| Molecular Weight: |
446.50 |
| Formula: |
C22H30N4O6 |
| Purity: |
≥98% |
| CAS#: |
1045792-66-2 |
| Solubility: |
DMSO up to 100 mM |
| Chemical Name: |
tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0.42 nM, 6851 nM, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM. It could be useful chemical probe to study HDAC biology.
How to Use:
In vitro: CAY10603 was used at 0.1-1 μM final concentration in various in vitro assays.
In vivo: n/a
Reference:
- 1. Kozikowski AP, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. (2008) J Med Chem. 51(15):4370-3.?
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Products are for research use only. Not for human use.
