AdipoRon,AdiponectinReceptor/AdipoRagonist
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產品名稱: AdipoRon,AdiponectinReceptor/AdipoRagonist
產品型號: M60152-2s
產品展商: 其它品牌
產品文檔: 無相關文檔
簡單介紹
AdipoRon,AdiponectinReceptor/AdipoRagonist
AdipoRon,AdiponectinReceptor/AdipoRagonist
的詳細介紹
Product Information
| Molecular Weight: |
428.52 |
| Formula: |
C27H28N2O3 |
| Purity: |
≥98% |
| CAS#: |
924416-43-3 |
| Solubility: |
DMSO up to 50 mM |
| Chemical Name: |
2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide |
| Storage: |
Powder: 4oC 1 year.
DMSO: 4oC 3 month;
-20oC 1 year. |
Biological Activity:
AdipoRon is a novel, highly potent, selective and orally active small molecule agonist of adiponectin receptor (AdipoR). AdipoRon binds to both AdipoR1 and AdipoR2 (EC50?for AdipoR1 ~1.8 μM and AdipoR2 ~3.1 μM). AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed with a high-fat diet, which was completely obliterated in AdipoR1 and AdipoR2 double-knockout mice. Moreover, AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon could serve as a very useful chemical probe for studies of obesity-related diseases such as type 2 diabetes by activating AdipoR1 and AdipoR2.?
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How to Use:
In vitro:? AdipoRon was used at 10-25 μM final concentration in vitro and in cellular assays.
In vivo:??AdipoRon was administered orally to mice at 50 mg/kg once per day.?
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Reference:
- 1. Okada-Iwabu, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. (2013) Nature. 503(7477):493-9.?
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Products are for research use only. Not for human use.
