For Research Use Only. Not for use in diagnostic procedures.

A murine monoclonal antibody to a neo-epitope expressed on iC3b.

This monoclonal antibody was raised against purified human iC3b. It is specific for a neo-antigen on iC3b.

Quidel's iC3b monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, Flow Cytometry, RIA, Hemagglutination and Immunohistochemistry. Please contact Quidel Technical Support for details on these or other applications.

References

Tamerius, J.D., Pangburn, M., et al. Detection of a neoantigen on human iC3b and C3d by monoclonal Antibody, J. Immunol. 135:2015, 1985.

Rogers, J., Cooper, N., et al. Complement Activation by ?-amyloid in Alzheimer disease, PNAS 89:10016-10020, 1992.

Gemmell, C. A flow cytometric immunoassay to quantify adsorption of complement activation products on artificial surfaces, J Biomed Mater Res 37, 474-480, 1997.

Merri, S., Junnikala, S. Exceptional Resistance of Human H2 Gioblastoma Cells to Complement Mediated Killing by Expression and Utilization of Factor H and Factor H Like Protein 1, J Immunol 164:11 6075-6081, 2000.

Marks, R., Hindmarsh, E. Complement activation occurs on subendothelial extracellular matrix in vitro and is initiated by retraction or removal of overlying endothelial cells, J Immunol 160:6128-6136, 1998.